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Neuro-Protection in Parkinson's Disease

A recent study has revealed that high-intensity exercise can enhance dopamine signalling in the brain, offering neuroprotective effects for individuals with Parkinson’s disease. This groundbreaking research, published in npj Parkinson's Disease, used imaging to confirm changes in brain biology due to intense physical activity. The study involved 10 early-stage Parkinson's patients who participated in a six-month high-intensity exercise program. Post-program brain imaging indicated increased dopamine levels for most participants, suggesting that vigorous exercise could significantly manage Parkinson's disease. The target HR was achieved in about two-thirds of all classes (i.e., 80% of the maximum HR). However, 90% of classes were rated as very intense by the subjects.




Parkinson's disease is a progressive neurological disorder primarily affecting movement. It develops due to the loss of neurons that produce dopamine in the brain, leading to symptoms like tremors, stiffness, and difficulty with balance and coordination. The exact cause remains unknown, though genetic and environmental factors are believed to contribute. There's no cure, but treatments, including medication and physical therapy, can help manage symptoms. This context underscores the importance of the recent study on high-intensity exercise and its potential to boost brain dopamine signalling in Parkinson's patients.



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